Enzyme-catalyzed chemoselective transesterification reactions on hydroxymethylated phenolic compounds

…, HN Pati, R Kumar, A Azim, S Roy, W Errington

Index: Parmar, Virinder S.; Prasad, Ashok K.; Pati, Hari N.; Kumar, Rajesh; Azim, Abul; Roy, Sucharita; Errington, William Bioorganic Chemistry, 1999 , vol. 27, # 2 p. 119 - 134

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Citation Number: 28

Abstract

The chemoselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran andCandida rugosalipase (CRL) in diisopropyl ether have been investigated for selective acetylation and deacetylation of hydroxymethylated phenols and hydroxyaryl alkyl ketones and their peracetylated derivatives. Both PPL and CRL exhibited exclusive selectivity for the acetylation of alcoholic hydroxyl group over the phenolic hydroxyl group (s) of the ...