N, N-bis (trimethylsilyl) methoxymethylamine as a convenient synthetic equivalent for+ CH 2 NH 2: primary aminomethylation of esters

K Okano, T Morimoto, M Sekiya

Index: Okano, Kohji; Morimoto, Toshiaki; Sekiya, Minoru Journal of the Chemical Society, Chemical Communications, 1984 , # 13 p. 883 - 884

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Citation Number: 18

Abstract

N,N-Bis(trimethylsilyl)methoxymethylamine as a Convenient Synthetic Equivalent for +CH2NH2: Primary Aminomethylation of Esters ... Kohji Okano, Toshiaki Moiimoto, and Minoru Sekiya” Shizuoka College of Pharmacy, Oshika, Shizuoka 422, Japan ... The introduction of a primary aminomethyl unit at the a position of esters can be achieved in high yield by the silyl t rif lu or0 met ha nesu I p honate-cata I ysed react ion of ketene si I yl aceta Is (2) with N, ...