Synthesis of new N-arylamino (2-furyl) methylphosphonic acid diesters, and in vitro evaluation of their cytotoxicity against esophageal cancer cells

AA Klimczak, A Kuropatwa, J Lewkowski…

Index: Klimczak, Anna Agnieszka; Kuropatwa, Agnieszka; Lewkowski, Jaroslaw; Szemraj, Janusz Medicinal Chemistry Research, 2013 , vol. 22, # 2 p. 852 - 860

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Citation Number: 9

Abstract

Abstract N-Furfurylideneanilines and N-arylamino (2-furyl) methylphosphonates with tolyl and anisyl moieties were synthesized by the addition of phosphites to azomethine bond of corresponding Schiff bases and their NMR spectroscopic properties were investigated. Then, they were analyzed in the point of view of their influence on KYSE 30, KYSE 150, and KYSE 270 esophageal cancer cell lines and on immortalized esophageal cell line HET 1 ...