Canadian Journal of Chemistry

Reaction on a solid surface-A simple, economical, and efficient Mannich reaction of azacrown ethers over graphite

H Sharghi, R Khalifeh

Index: Sharghi, Hashem; Khalifeh, Reza Canadian Journal of Chemistry, 2008 , vol. 86, # 5 p. 426 - 434

Full Text: HTML

Citation Number: 16

Abstract

Graphite brings about a rapid Mannich reaction with a range of activated and unactivated phenolic compounds such as p-cresol and p-nitrophenol. The reactions are carried out with azacrown ether and paraformaldehyde in solvent-free conditions at 100° C for 20-30 min. The graphite powder can be reused up to three times after simple washing with acetone. Key words: azacrown ether, lariat ether, graphite, solvent-free, Mannich reaction.