Noncoincidence of the anxiolytic, sedative, and antispasmodic properties in harman derivatives

…, AT Dolzhenko, LY Zin'kovskaya, YA Nilolyukin…

Index: Komissarov, I. V.; Dulenko, V. I.; Dolzhenko, A. T.; Zin'kovskaya, L. Ya.; Nilolyukin, Yu. A.; et al. Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 3 p. 187 - 190 Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 3 p. 172 - 176

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Abstract

Many B-oarbolines [8, I0], in particular, norharman [8], harman [8, 13], and esters of B- carboline-3-carboxylic acid [9, i0], interact with high affinity with the specific binding sites of benzodiazepine tranquilizers (BD) in membrane fragments of the brain. These ligands of the benzodiazepine receptors are considered as agonists (antibenzodiazepines), since they induce convulsions that can be eliminated with BD [14, 16], while certain B-carbolines ...