Palladium-catalyzed phosphonylation: synthesis of C3-, C4-, and C5-phosphonylated pyrazoles

G Tran, D Gomez Pardo, T Tsuchiya, S Hillebrand…

Index: Tran, Gael; Pardo, Domingo Gomez; Tsuchiya, Tomoki; Hillebrand, Stefan; Vors, Jean-Pierre; Cossy, Janine Organic Letters, 2013 , vol. 15, # 21 p. 5550 - 5553

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Citation Number: 7

Abstract

A palladium-catalyzed cross-coupling between 3-, 4-, and 5-halo-pyrazoles and H- phosphonates, H-phosphinates, and secondary phosphine oxides has been developed. This coupling reaction constitutes the first general method allowing the introduction of a great diversity of phosphorus substituents on the different carbons of the pyrazole ring in a one-step process.

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