A General Palladium??Catalyzed Sonogashira Coupling of Aryl and Heteroaryl Tosylates

O R'kyek, N Halland, A Lindenschmidt…

Index: R'kyek, Omar; Halland, Nis; Lindenschmidt, Andreas; Alonso, Jorge; Lindemann, Peter; Urmann, Matthias; Nazare, Marc Chemistry - A European Journal, 2010 , vol. 16, # 33 p. 9986 - 9989

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Citation Number: 19

Abstract

Aryl alkynes are important synthetic precursors for a wide variety of target compounds.[1] The most straightforward and reliable method for the regioselective construction of these intermediates is the palladium-catalyzed Sonogashira coupling.[2] Considerable efforts have been made to enhance the efficiency and generality of this reaction. Several palladium catalyst systems have been developed that enable the reaction to proceed at room ...