Medicinal Chemistry Research

Synthesis, computational studies, and preliminary pharmacological evaluation of new arylpiperazines as potential antipsychotics

S Kumar, AK Wahi, R Singh

Index: Kumar, Sushil; Wahi; Singh, Ranjit Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1218 - 1225

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Abstract

Abstract A series of long-chain arylpiperazines bearing a salicylamide fragment were synthesized, and the target compounds were evaluated for atypical antipsychotic activity in apomorphine-induced climbing behavior (D 2 antagonism) and 5-HTP-induced head twitches (5-HT 2A antagonism) along with catalepsy studies in mice. The physicochemical similarity values of the target compounds with respect to standard drugs, clozapine, ...