Organic letters

Palladium-catalyzed coupling of polyfluorinated arenes with heteroarenes via C–F/C–H activation

D Yu, L Lu, Q Shen

Index: Yu, Daohong; Lu, Long; Shen, Qilong Organic Letters, 2013 , vol. 15, # 4 p. 940 - 943

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Citation Number: 27

Abstract

The first palladium-catalyzed coupling of 2-pyridyl-polyfluoroarenes and benzoxazole, thiazole, benzothiazole, benzoimidazole, oxazole or oxadiazole via a concurrent C–F/C–H activation is described. Initial mechanistic studies showed that C–F activation of perfluoroarene is likely the rate-limiting step of the catalytic cycle. This protocol provides a useful and operationally simple process to functionalized polyfluoroarenes.