Chinese Journal of Chemistry

Efficient Synthesis of the Functionalized Spiro [indoline??3, 4′??pyridine] via Four??component Reaction

J Sun, Q Wu, L Zhang, C Yan

Index: Sun, Jing; Wu, Qun; Zhang, Lijuan; Yan, Chaoguo Chinese Journal of Chemistry, 2012 , vol. 30, # 7 p. 1548 - 1554

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Citation Number: 14

Abstract

Abstract An efficient synthetic procedure for the functionalized spiro [indoline-3, 4′-pyridine] was developed via the four-component reactions of arylamines, acetylenedicarboxylates, isatins and malononitrile with triethylamine as the base catalyst. The advantages of this reaction are using common starting material, mild reaction conditions, broad scope of reactants and operational simplicity.