Organic letters

Simplification of the Mitsunobu reaction. Di-p-chlorobenzyl azodicarboxylate: a new azodicarboxylate

BH Lipshutz, DW Chung, B Rich, R Corral

Index: Lipshutz, Bruce H.; Chung, David W.; Rich, Brian; Corral, Ricardo Organic Letters, 2006 , vol. 8, # 22 p. 5069 - 5072

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Citation Number: 64

Abstract

The Mitsunobu coupling is among an elite group within a vast array of name reactions. 1 It is used so frequently that oftentimes literature reviews, 2 as well as its origins, 3 are excluded from among the citations. These reactions rely on an initial adduct 1 formed between Ph 3 P and an azodicarboxylate, with the diethyl derivative (ie, DEAD; Figure 1) credited with the majority of reported examples. 2 The diisopropyl ester (DIAD) is also very commonly utilized. 2 ...

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