Identification of sequence selective receptors for peptides with a carboxylic acid terminus

T Braxmeier, M Demarcus, T Fessmann…

Index: Braxmeier, Tobias; Demarcus, Mariangela; Fessmann, Thilo; McAteer, Stephen; Kilburn, Jeremy D. Chemistry - A European Journal, 2001 , vol. 7, # 9 p. 1889 - 1898

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Citation Number: 40

Abstract

Abstract Split-and-mix libraries of resin-bound “tweezer” receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO 2 H group, leading to strong and selective receptors for peptide guests with a CO 2 H terminus. The role of the dye- label, attached to the peptide guest to allow visualisation of selective recognition events in ...