Tetrahedron

Tetronic acids and derivatives-IV: Synthesis and lactonization of-γ-acetoxy β-ketoesters

P Pollet, S Gelin

Index: Pollet,P.; Gelin,S. Tetrahedron, 1978 , vol. 34, p. 1453 - 1455

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Citation Number: 30

Abstract

Through our investigation of synthetic routes to tetronic acids, elaboration and cyclization of γ-acetoxy-β-ketoesters were examined. Synthesis of these β-ketoesters 2 has been realized by selective monoacylation of the magnesioenolate of monoethyl malonate. Lactonization of 2 leading to tetronic acids or to 4-alkoxy-furan-2 (5H)-ones is reported.

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