Catalytic direct 1, 4-conjugate addition of aldehydes to vinylketones on secondary-amines immobilised in FSM-16 silica

…, H Suzuki, E Hayashi, T Kodama, Y Tsuchiya…

Index: Shimizu, Ken-Ichi; Suzuki, Hiromasa; Hayashi, Eidai; Kodama, Tatsuya; Tsuchiya, Yoshimi; Hagiwara, Hisahiro; Kitayama, Yoshie Chemical Communications, 2002 , # 10 p. 1068 - 1069

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Citation Number: 27

Abstract

Substituted 5-ketoaldehydes 3 have been important synthons especially for substituted cyclohex-2-en-1-one derivatives which have been versatile starting materials for synthesis of natural products such as terpenoids. Because of the difficulty in controlling high reactivity of formyl groups, the synthesis of 5-ketoaldehydes 3 has been accomplished via several-pot reaction via 1,4-addition of masked aldehydes such as enamines or silylenol ethers in the ...