Bis-basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 5. Bis-basic ethers of anthraquinone and bisalkamine esters of …

…, ER Andrews, FW Sweet, JW Hoffman…

Index: Sill; Andrews; Sweet; Hoffman; Tiernan; Grisar; Fleming; Mayer Journal of Medicinal Chemistry, 1974 , vol. 17, # 9 p. 965 - 968

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Citation Number: 25

Abstract

2, 6-Bis [2-(diethylamino) ethoxy]-9, lO-anthracenedione dihydrochloride (10, RMI 10,024 DA) was found to prolong survival of mice infected with lethal challenges of encephalomyocarditis (EMC) virus. It was effective by oral as well as subcutaneous administration and showed broad spectrum antiviral activity. It was selected for preclinical evaluation from a series of congeners that were synthesized to determine structure-activity ...