Synthesis of three oxytocin analogs related to [1-deaminopenicillamine] oxytocin prossessing antioxytocic activity

…, DH Rich, AT Blomquist, V Du Vigneaud

Index: Vavrek; Ferger; Allen; Rich; Blomquist; Du Vigneaud Journal of medicinal chemistry, 1972 , vol. 15, # 2 p. 123 - 126

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Citation Number: 32

Abstract

[1-Mercaptodimethylacetic acidloxytocin,[l+'-mercapto-a, a-dimethylpropionic acidloxytocin, and [1-P-mercapto-0, P-diethylpropionic acidloxytocin, analogs of deaminopenicillamine- oxytocin, have been synthesized from a common protected octapeptide resin intermediate and purified by sequential gel fil-tration on Sephadex G-15 in 50% AcOH and 0.2 N AcOH. The 3 compounds were devoid of oxytocic and avian vasodepressor activities, but all ...

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