The Journal of Organic Chemistry

Defined dimensional alterations in enzyme substrates. lin-Naphthoadenine and lin-naphthoadenosine

TM Stevenson, NJ Leonard

Index: Stevenson, Thomas M.; Leonard, Nelson J. Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2158 - 2164

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Citation Number: 11

Abstract

Chemistry. Due to the difficulty encountered previously in forming the imidazole ring late in the reaction sequence leading to a lin-naphthopurine, 2 we planned to generate the o- xylylene with an imidazole ring already in place. Since we were aware of reports of the N- bromosuccinimide bromination of some N-substituted aminoxylenes on the nucleus as well as the side chain5 and of methylimidazoles at C-2 in preference to the methyl group: we ...