Efficient synthesis of a new potential chelating agent for radioimmunotherapy
…, P Remaud, A Faivre-Chauvet, JC Meslin, D Deniaud
Index: Gouin, Sebastien G.; Gestin, Jean-Francois; Remaud, Patricia; Faivre-Chauvet, Alain; Meslin, Jean Claude; Deniaud, David Synlett, 2002 , # 12 p. 2080 - 2082
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Citation Number: 3
Abstract
Abstract The synthesis of a new rigid analogue of cyclohexyl-TTHA, an efficient lanthanide ligand, as well, as the first complexation trials are reported. This polyaminopolycarboxylic acid, Ph-DTHA 1, was obtained in five steps from phenylenediamine as starting product. The key intermediate was phenylenediethylenetetraamine 4, which after alkylation and hydrolysis gave the expected compound 1 with ten coordination centers.
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[Gouin, Sebastien G.; Gestin, Jean-Francois; Monrandeau, Laurence; Segat-Dioury, Fabienne; Meslin, Jean Claude; Deniaud, David Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 454 - 461]
[Gouin, Sebastien G.; Gestin, Jean-Francois; Monrandeau, Laurence; Segat-Dioury, Fabienne; Meslin, Jean Claude; Deniaud, David Organic and Biomolecular Chemistry, 2005 , vol. 3, # 3 p. 454 - 461]