Erik M. van Oosten, Alan A. Wilson, David C. Mamo, Bruce G. Pollock

BH Mulsant, S Houle, N Vasdev

Index: Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232

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Abstract

Abstract: Muscarinic receptors have been implicated in neurological disorders including Alzheimer's disease, Parkinson's disease, and schizophrenia. Nineteen derivatives of thiadiazolyltetrahydropyridine (TZTP), a core that has previously shown high affinities towards muscarinic receptor subtypes, were synthesized and evaluated via in vitro binding assays. The title compound, a fluoro-polyethyleneglycol analog of TZTP (4c), was ...