Atom??Economic and Stereoselective Syntheses of the Ring A and B Subunits of the Bryostatins

BM Trost, H Yang, CS Brindle…

Index: Trost, Barry M.; Yang, Hanbiao; Brindle, Cheyenne S.; Dong, Guangbin Chemistry - A European Journal, 2011 , vol. 17, # 35 p. 9777 - 9788

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Citation Number: 14

Abstract

Abstract This article describes chemoselective and atom-economic methods for the stereoselective assembly of the ring A and B subunits of bryostatins. A Ru-catalyzed tandem alkene–alkyne coupling/Michael addition reaction was developed and applied to the synthesis of bryostatin ring B. We explored an acetylide-mediated epoxide-opening/6-exo- dig cyclization route to access the bryostatin ring A, although ring A was eventually ...