Organic letters

Monofluorovinyl Tosylate: A Useful Building Block for the Synthesis of Terminal Vinyl Monofluorides via Suzuki− Miyaura Coupling

H Zhang, CB Zhou, QY Chen, JC Xiao, R Hong

Index: Zhang, He; Zhou, Chang-Bing; Chen, Qing-Yun; Xiao, Ji-Chang; Hong, Ran Organic Letters, 2011 , vol. 13, # 4 p. 560 - 563

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Citation Number: 38

Abstract

Monofluorovinyl tosylate was developed as a practical vinyl fluoride building block to couple with a variety of arylboronic acids in the presence of a palladium catalyst. The high stereoselectivity of 2-aryl-1-fluoroethene derivatives was achieved. This approach is also applicable to the synthesis of 2, 2-diaryl-1-fluoroethenes in good yields.

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