Synlett

Observations on the reaction of N-alkyloxazolidines, isocyanides and carboxylic acids: A novel three-component reaction leading to N-acyloxyethylamino acid amides

LJ Diorazio, WB Motherwell, TD Sheppard, RW Waller

Index: Diorazio, Louis J.; Motherwell, William B.; Sheppard, Tom D.; Waller, Robert W. Synlett, 2006 , # 14 p. 2281 - 2283

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Citation Number: 7

Abstract

Abstract N-Alkyloxazolidines, readily prepared by condensation of the parent carbonyl compounds with β-aminoalcohols, were found to undergo three-component reactions with isocyanides and carboxylic acids to give N-acyloxyethylamino acid derivatives in good yield. The reaction allows the variation of substituents at five different sites in the products through suitable choice of reagents.