Bioorganic & medicinal chemistry letters

Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α 1-adrenoceptor antagonists

MY Li, H Fang, L Xia

Index: Li, Min-Yong; Fang, Hao; Xia, Lin Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 13 p. 3216 - 3219

Full Text: HTML

Citation Number: 37

Abstract

Phenyl-piperazines were designed and synthesized based on pharmacophore for uro- selective α1-adrenoceptor antagonists and 3D chemical database searching. Within this series, three compounds, 2, 3, and 13, showed similar or better α1-AR antagonistic activity compared with prazosin. The 3D-QSAR study of these compounds may provide useful information for the development of novel aryl-piperazines as uro-selective α1- ...

Related Articles:

Synthesis and biological evaluation of new [Tc (N)(PS)]-based mixed-ligand compounds useful in the design of target-specific radiopharmaceuticals: the 2- …

[Bolzati, Cristina; Salvarese, Nicola; Carta, Davide; Refosco, Fiorenzo; Dolmella, Alessandro; Pietzsch, Hans Juergen; Bergmann, Ralf; Bandoli, Giuliano Journal of Biological Inorganic Chemistry, 2011 , vol. 16, # 1 p. 137 - 155]

Novel 5-HT7 receptor inverse agonists. Synthesis and molecular modeling of arylpiperazine-and 1, 2, 3, 4-tetrahydroisoquinoline-based arylsulfonamides

[Vermeulen, Erik S; van Smeden, Marjan; Schmidt, Anne W; Sprouse, Jeffrey S; Wikstroem, Hakan V; Grol, Cor J Journal of medicinal chemistry, 2004 , vol. 47, # 22 p. 5451 - 5466]

More Articles...