Synthetic Communications

The Wittig reaction using potassium-tert-butoxide high yield methylenations of sterically hindered ketones

L Fitjer, U Quabeck

Index: Fitjer, Lutz; Quabeck, Ulrike Synthetic Communications, 1985 , vol. 15, # 10 p. 855 - 864

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Citation Number: 111

Abstract

ABSTRACT: Potassium-tert-butoxide is recommended for ge- neral use in Wittig reactions with nonstabilized ylides. High yield methylenationsofcyclohexanone andaseries of five sterically hindered ketones demonstrate its utility. ... When choosing a base for the ylide-forming step of the ... (1) alkyllithium compounds may give rise to an attack on ... It therefore seems obvious that potassium-containing ba- ... Potassium-tert-butoxide has long been known to accele-

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