Probing the mechanism of bioactivation of MPTP type analogs by monoamine oxidase B: structure-activity studies on substituted 4-phenoxy-, 4-phenyl-, and 4- …

…, AH Anderson, H Burch, N Castagnoli Jr

Index: Rimoldi, John M.; Wang, You-Xiong; Nimkar, Sandeep K.; Kuttab, Simon H.; Anderson, Andrea H.; Burch, Heidi; Castagnoli, Neal Chemical Research in Toxicology, 1995 , vol. 8, # 5 p. 703 - 710

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Citation Number: 24

Abstract

Previous studies have shown that 4-benzyl-l-cyclopropyl-1, 2, 3, 6-tetrahydropyridine is an excellent monoamine oxidase B (MAO-B) substrate (K,, JKM= 1538 min-l mM-') although the corresponding 4-phenyl analog displays MAO-B inactivating properties only. This behavior led us to speculate that the pathway for the MAO-B catalyzed oxidation of these tetrahydropyridines may not necessarily proceed via an initial single electron transfer step ...