Tetrahedron Letters

Solid-phase Friedel–Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3, 5-dihydro-4H-2, 3-benzodiazepin-4-ones

F Bevacqua, A Basso, R Gitto, M Bradley, A Chimirri

Index: Bevacqua, Francesca; Basso, Andrea; Gitto, Rosaria; Bradley, Mark; Chimirri, Alba Tetrahedron Letters, 2001 , vol. 42, # 43 p. 7683 - 7685

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Citation Number: 33

Abstract

Friedel–Crafts acylation with various acyl chlorides of resin-bound 3, 4- dimethoxyphenylacetate afforded resin bound ketones which, following treatment with hydrazine, were converted into the corresponding 2, 3-benzodiazepines in good yields and purities.

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