Crossed aldol reaction using cross-linked polymer-bound lithium dialkylamide

A Seki, F Ishiwata, Y Takizawa, M Asami

Index: Seki, Atsushi; Ishiwata, Fusae; Takizawa, Youichi; Asami, Masatoshi Tetrahedron, 2004 , vol. 60, # 23 p. 5001 - 5011

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Citation Number: 20

Abstract

Cross-linked polymer-bound lithium dialkylamides were employed in crossed aldol reaction of various carbonyl compounds with aldehydes to afford the corresponding β- hydroxycarbonyl compounds. The introduction of spacer chains to the polymer-bound lithium dialkylamide between the base moiety and the polystyrene backbone effectively enhanced yields of the desired aldol adducts. Sometimes better yields were obtained by ...