7, 8-Dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes

…, O Fedorov, C Gasser, P Filippakopoulos…

Index: Wakamatsu, Takeshi; Inaki, Harumi; Ogawa, Akemi; Watanabe, Masako; Ban, Yoshio Heterocycles, 1980 , vol. 14, # 10 p. 1437 - 1440

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Citation Number: 39

Abstract

... Volume: Page: ... the pyridone ring of alkaloid 1 is replaced by a pyridazinone, ethyl 6,7-dichloroindole-2-carboxylate (13)(10) was alkylated with methyl iodide in DMF after deprotonation with sodium hydride to give N-methylated indole 14 (Scheme 1A ...