Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice

…, Y Imanishi, P Leahy, R Kubota, K Palczewski

Index: Maeda, Akiko; Maeda, Tadao; Golczak, Marcin; Imanishi, Yoshikazu; Leahy, Patrick; Kubota, Ryo; Palczewski, Krzysztof Molecular Pharmacology, 2006 , vol. 70, # 4 p. 1220 - 1229

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Citation Number: 67

Abstract

Abstract Regeneration of the chromophore 11-cis-retinal is essential for the generation of light-sensitive visual pigments in the vertebrate retina. A deficiency in 11-cis-retinal production leads to congenital blindness in humans; however, a buildup of the photoisomerized chromophore can also be detrimental. Such is the case when the photoisomerized all-trans-retinal is produced but cannot be efficiently cleared from the ...