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Characterization and preliminary use of 1-, 2-and 3-methyl-5-phenyl-7-chloro-1, 2, 3-triazolo [4, 5-d] pyrimidine as reaction intermediates

G Biagi, I Giorgi, O Livi, V Scartoni, PL Barili

Index: Biagi, Giuliana; Giorgi, Irene; Livi, Oreste; Scartoni, Valerio; Barili, Pier Luigi Farmaco, 2003 , vol. 58, # 8 p. 551 - 556

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Citation Number: 4

Abstract

This paper reports synthesis and characterization, by spectroscopic methods, of three new N- methyl-5-phenyl-7-chloro-1, 2, 3-triazolo [4, 5-d] pyrimidine isomers 3a, 3b and 3c. For comparison purpose the 3-benzyl-5-phenyl-7-chloro-1, 2, 3-triazolo [4, 5-d] pyrimidine (7) was also prepared. Starting from the isomer mixture 3a–c and the chloroderivative 7, by nucleophilic substitution reaction with ethyl carbazate and subsequent intramolecular ...

2, 9-Disubstituted-N 6-(arylcarbamoyl)-8-azaadenines as new selective A 3 adenosine receptor antagonists: synthesis, biochemical and molecular modelling studies

[Biagi, Giuliana; Bianucci, Anna Maria; Coi, Alessio; Costa, Barbara; Fabbrini, Laura; Giorgi, Irene; Livi, Oreste; Micco, Iolanda; Pacchini, Federica; Santini, Edoardo; Leonardi, Michele; Nofal, Fatena Ahmad; Salerni, Oreste LeRoy; Scartoni, Valerio Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4679 - 4693]

2, 9-Disubstituted-N 6-(arylcarbamoyl)-8-azaadenines as new selective A 3 adenosine receptor antagonists: synthesis, biochemical and molecular modelling studies

Characterization and preliminary use of 1-, 2-and 3-methyl-5-phenyl-7-chloro-1, 2, 3-triazolo [4, 5-d] pyrimidine as reaction intermediates

Abstract

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