Synthesis and evaluation of imidazo [1, 5-a] pyrazines as corticotropin releasing hormone receptor ligands

…, KK Nanda, AJ Tebben, LW Fitzgerald, K Miller

Index: Hartz, Richard A.; Gilligan, Paul J.; Nanda, Kausik K.; Tebben, Andrew J.; Fitzgerald, Larry W.; Miller, Keith Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 3 p. 291 - 294

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Citation Number: 21

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel series of imidazo[1,5-a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored.