Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy

…, K Sana, D Yan, SA Krumm, P Thepchatri…

Index: Moore, Terry W.; Sana, Kasinath; Yan, Dan; Krumm, Stefanie A.; Thepchatri, Pahk; Snyder, James P.; Marengo, Jose; Arrendale, Richard F.; Prussia, Andrew J.; Natchus, Michael G.; Liotta, Dennis C.; Plemper, Richard K.; Sun, Aiming ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 8 p. 762 - 767

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Citation Number: 12

Abstract

Targeting host cell factors required for virus replication provides an alternative to targeting pathogen components and represents a promising approach to develop broad-spectrum antiviral therapeutics. High-throughput screening (HTS) identified two classes of inhibitors (2 and 3) with broad-spectrum antiviral activity against ortho-and paramyxoviruses including influenza A virus (IAV), measles virus (MeV), respiratory syncytial virus (RSV), and human ...

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