Synthesis of Potentially β??Blocking Practolol Derivatives:(E+ Z)??3??[4??(3??Iodoprop??2??enyloxycarbonylamino) phenoxy]??1??(isopropylamino) propan??2??ol

M Apparu, YB Tiba, PM Léo…

Index: Apparu, Marcel; Ben Tiba, Younes; Leo, Pierre-Marc; Fagret, Daniel European Journal of Organic Chemistry, 2000 , # 6 p. 1007 - 1012

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Abstract

Abstract The iodinatied carbamates 3 (E+ Z), with potential β-blocking properties, were synthesized. The first route chosen, from 4-aminophenol and the chloroformate β7, had to be abandoned because of the formation of the oxazolidinone 10 during the epoxidation step. The aminoalcohol 17 prepared from the practolol 1 finally gave the target compounds by condensation with the iodoallylic chloroformates 8 (E+ Z). The secondary Boc-protected ...