Allylation of carbon pronucleophiles with alkynes in the presence of palladium/acetic acid catalyst

…, A Shibuya, YS Gyoung, Y Yamamoto

Index: Patil, Nitin T.; Kadota, Isao; Shibuya, Akinori; Young, Soo Gyoung; Yamamoto, Yoshinori Advanced Synthesis and Catalysis, 2004 , vol. 346, # 7 p. 800 - 804

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Citation Number: 26

Abstract

Abstract We have developed an efficient and eco-chemical process for the allylation of carbon pronucleophiles with alkynes. The reaction of alkynes with various active methynes and methylenes in the presence of Pd (PPh 3) 4/acetic acid gave the corresponding allylated products in high yields and high regioselectivities. In the present catalytic system, the key is the use of carboxylic acid which dramatically enhances the rate of the reactions. ...