Synthesis and evaluation of estrogen agonism of diaryl 4, 5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1, 3-diketones: a compound set forming a …

JT Pulkkinen, P Honkakoski…

Index: Pulkkinen, Juha T.; Honkakoski, Paavo; Peraekylae, Mikael; Berczi, Istvan; Laatikainen, Reino Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3562 - 3571

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Citation Number: 31

Abstract

In this paper, the preparation and systematic evaluation of estrogen receptor α (ERα) and estrogen receptor β (ERβ) activities of some diaryl-1, 3-diones and their synthetic intermediates, diaryl-4, 5-dihydroisoxazoles, diaryl-3-hydroxyketones, diaryl-3- methoxyketones, and diaryl-2-(dimethyl-λ4-sulfanylidene)-1, 3-diones, is described. The set of 72 compounds constitutes a general schematic structure aryl1− linker1− spacer− ...

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