Tetrahedron

Efficient copper (I)-catalyzed coupling of secondary phosphine oxides with aryl halides

M Stankevič, A Włodarczyk

Index: Stankevic, Marek; Wlodarczyk, Adam Tetrahedron, 2013 , vol. 69, # 1 p. 73 - 81

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Citation Number: 14

Abstract

A catalytic system has been developed for the efficient synthesis of tertiary arylphosphine oxides by coupling of readily available secondary phosphine oxides with aryl bromides or iodides in the presence of copper (I) iodide as a catalyst and (S)-α-phenylethylamine as a ligand. The system exhibits high activity in the coupling of secondary diaryl-, alkylaryl-and dialkylphosphine oxides.