Synthesis and Photooxygenation of Furo [3, 2??c] coumarin Derivatives as Antibacterial and DNA Intercalating Agent

AG Al??Sehemi, SR El??Gogary

Index: Al-Sehemi, Abdullah G.; El-Gogary, Sameh R. Chinese Journal of Chemistry, 2012 , vol. 30, # 2 p. 316 - 320

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Citation Number: 18

Abstract

Abstract Syntheses of 2, 3-dimethyl-4H-furo [3, 2-c] coumarin and 3-phenyl-4H-furo [3, 2-c] coumarin as angular furocoumarins were carried out through Williamson reaction of 4- hydroxycoumarin with α-haloketones followed by cyclization. Photooxygenation of the synthesized furocoumarin derivatives was performed and the photoproducts were isolated and characterized. The affinity of 2, 3-dimethyl-4H-furo [3, 2-c] coumarin towards DNA and ...