(R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis

…, JS Mills, JG Montana, R Tacke, JBH Warneck

Index: Showell, Graham A.; Barnes, Matthew J.; Daiss, Juergen O.; Mills, John S.; Montana, John G.; Tacke, Reinhold; Warneck, Julie B. H. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 9 p. 2555 - 2558

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Citation Number: 35

Abstract

Sila-substitution of drugs (the carbon/silicon switch) is a concept that is being successfully used for the development of new chemical entities. The (R)-sila-analogue of the antidepressant venlafaxine is devoid of the serotonin reuptake inhibition observed with the marketed drug, leading to a selective noradrenaline reuptake inhibitor displaying anti-emetic properties.