A Short and Efficient Synthesis of a Novel Diarylheptanoid Isolated from Pleuranthodium Racemigerum
CY Chang
Index: Chang, Ching-Yao Journal of the Chinese Chemical Society, 2011 , vol. 58, # 3 p. 286 - 289
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Citation Number: 3
Abstract
Abstract The first total synthesis of the linear diarylheptanoid 1-(4 ″-methoxyphenyl)-7-(4′- hydroxyphenyl)-(E)-hept-2-ene, which has a uniquely nonconjugated olefin, was achieved. The synthetic route employed an olefin cross-metathesis as a key step. Beginning with commercially available 3-(4-hydroxyphenyl) propan-1-ol, the final product was made in three steps with a 52% yield.
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[Tamiz, Amir P.; Whittemore, Edward R.; Woodward, Richard M.; Upasani, Ravindra B.; Keana, John F.W. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1619 - 1624]
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