Mannich??type condensation reactions of sulfinic acids with aldehydes and nitrogen bases: Part. VI. The use of ureas, thioureas and thiobenzamide

H Meijer, RM Tel, J Strating…

Index: Meijer,H. et al. Recueil des Travaux Chimiques des Pays-Bas, 1973 , vol. 92, p. 72 - 82

Full Text: HTML

Citation Number: 18

Abstract

Abstract Urea, thiourea and some N′-alkyl (di) substituted ureas and thioureas were found to react as the amine component in Mannich-type condensation reactions with p-toluene-or phenylmethane-sulfinic acid and aldehydes. Mono-or di-alkylation products are formed in good yields depending on the N′-and N′-substituents in the substrate, while N, N, N′- trimethylurea or-thiourea failed to react. N′-Hydroxy-N′-phenylthiourea is alkylated on ...