Journal of medicinal chemistry

Potential bioreductive alkylating agents. 3. Synthesis and antineoplastic activity of acetoxymethyl and corresponding ethyl carbamate derivatives of benzoquinones

AJ Lin, CW Shansky, AC Sartorelli

Index: Lin,A.J. et al. Journal of Medicinal Chemistry, 1974 , vol. 17, p. 558 - 561

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Citation Number: 36

Abstract

A number of benzo-and naphthoquinone derivatives with one or two side chains capable of alkylation after reduction were found (a) to possess inhibitory activity against the growth of transplantable tumors of mice and (b) to cause inhibition of nucleic acid biosynthesis and of the activities of coenzyme Q mediated enzyme systems.'-3 I n vivo conversion to an active form is hypothesized to in-volve reduction, presumably by a pyridine nucleotide-requiring ...