Microwave prompted multigram synthesis, structural determination, and photo-antiproliferative activity of fluorinated 4-hydroxyquinolinones

K Arya, M Agarwal

Index: Arya, Kapil; Agarwal, Manish Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 86 - 93

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Citation Number: 34

Abstract

3-Unsubstituted 4-hydroxyquinolin-2 (1H)-one containing F and CF3 substituent in ring is important pharmacological and synthetic target and basic synthones for a number of antibacterial fluoroquinolones and is promising potent and selective glycine site NMDA receptors. A simple facile one-step microwave enhanced multigram synthesis of such fluorinated quinolones in reasonable purity has been developed in excellent yield (85–94 ...