Transition-Metal-Catalyzed Chemoselective Methylenation of Dicarbonyl Substrates

H Lebel, M Davi, GT Stokłosa

Index: Lebel, Helene; Davi, Michael; Stoklosa, Grzegorz T. Journal of Organic Chemistry, 2008 , vol. 73, # 17 p. 6828 - 6830

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Citation Number: 6

Abstract

Rhodium-and copper-catalyzed methylenation reactions with trimethylsilyldiazomethane, triphenylphosphine, and 2-propanol were used to react chemoselectively with aldehydes, alkoxymethylketones, and trifluoromethylketones in substrates also containing a less reactive carbonyl group. Terminal alkenes were obtained in high yields, and no protecting group was necessary in the methylenation process.