A Concise and Efficient Synthesis of seco??Duocarmycin SA

…, F Haunert, T Feuerstein, T Herzig

Index: Tietze, Lutz F.; Haunert, Frank; Feuerstein, Tim; Herzig, Tobias European Journal of Organic Chemistry, 2003 , # 3 p. 562 - 566

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Citation Number: 21

Abstract

Abstract A short and efficient synthesis of seco-duocarmycin SA (3), a highly potent cytostatic agent and direct precursor of the natural product duocarmycin SA (1), has been achieved. Starting from commercially available 2-methoxy-4-nitroaniline (4) the synthetic protocol contains a Fischer indole synthesis to introduce the heterocyclic scaffold and a radical 5-exo- trig cyclization to furnish the (chloromethyl) indoline ring system as key reactions.(© Wiley- ...