Synthesis and antigastric ulcer activity of novel 5-isoproyl-3, 8-dimethylazulene derivatives

LY Zhang, F Yang, WQ Shi, P Zhang, Y Li…

Index: Zhang, Lu-Yun; Yang, Fang; Shi, Wan-Qi; Zhang, Ping; Li, Ying; Yin, Shu-Fan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5722 - 5725

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Citation Number: 13

Abstract

5-Isoproyl-3, 8-dimethylazulene derivatives were synthesized and evaluated for antigastric ulcer activity in vivo. Some of them possess the best activity against gastric ulcer with ulcer index values lower than the drug reference (omeprazole). The structure–activity relationship (SAR) shows that the lipophilic flat structure contributes to quite potent antigastric ulcer activity.