Syntheses of some ω-(1, 2, 3, 6-tetrahydro-1-pyridyl)-1-alkanols

…, J Lávička, S Kafka, M Ferles

Index: Silhankova, Alexandra; Lavicka, Jiri; Kafka, Stanislav; Ferles, Miloslav Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1435 - 1439

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Abstract

Abstract Quaternary salts of pyridine and 4-methylpyridine with ethyl esters of ω- bromoalkanoic acids, IIa-IIe, were converted into esters IIIa-IIIe by the action of sodium borohydride. These were further reduced by lithium aluminium hydride to alcohols Ia-Ie. 4- (1, 2, 3, 6-Tetrahydro-1-pyridyl)-butanol (Ic) was also obtained from 1-(3- ethoxycarbonylpropyl) pyridinium bromide (IIc) by the action of LiAlH 4. The ethyl ester IIIa ...