Integrated Catalytic C− H Transformations for One-Pot Synthesis of 1-Arylisoindoles from Isoindolines via Palladium-Catalyzed Dehydrogenation Followed by C− H …

T Ohmura, A Kijima, M Suginome

Index: Ohmura, Toshimichi; Kijima, Akihito; Suginome, Michinori Organic Letters, 2011 , vol. 13, # 5 p. 1238 - 1241

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Citation Number: 22

Abstract

Our recent interest has been directed to the development of a new concept for the synthesis of isoindole derivatives utilizing catalytic C−H transformations (Scheme 1).(6, 7) To avoid isolation of the air-sensitive isoindoles that are subjected to functionalization,(8) we particularly focused on cascade transformations starting from isoindolines, which are easy to handle and are easily available via several synthetic methods.(9) In this regard, we have established a ...