Aspartame decomposition and epimerization in the diketopiperazine and dipeptide products as a function of pH and temperature

SM Gaines, JL Bada

Index: Gaines, Susan M.; Bada, Jeffrey L. Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2757 - 2764

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Citation Number: 40

Abstract

Cyclization and hydrolysis of aspartame were studied over a range of pH and temperatures by using an HPLC method which allows simultaneous analysis of the diastereomeric dipeptide and diketopiperazine products. The pH dependence of aspartic acid and phenylalanine racemization rates in the dipeptide-diketopiperazine system resulting from aspartame decomposition was determined. On the basis of these studies a general ...