Steric course of N5, N10-methylenetetrahydrofolate formation from glycine by the glycine cleavage system in E. coli

DJ Aberhart, DJ Russell

Index: Aberhart, D. John; Russell, David J. Journal of the American Chemical Society, 1984 , vol. 106, # 17 p. 4907 - 4910

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Citation Number: 7

Abstract

Abstract: The steric course of the conversion of glycine to 5, lO-methylenetetrahydrofolate (5, lO-CH2-H4folate) by the glycine cleavage system in E. coli has been elucidated. 2-H, e of glycine is the precursor of 11-H, of 5, lO-CH2-H, folate, and 2-Hsi of glycine is the precursor of 1 l-Hsi of 5, lO-CH2-H4folate. The overall transformation is at least 78% stereospecific (possibly higher).