Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs

D Gibson, I Binyamin, M Haj, I Ringel, A Ramu…

Index: Gibson; Binyamin; Haj; Ringel; Ramu; Katzhendler European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 823 - 831

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Citation Number: 39

Abstract

A series of complexes PtAm2L [where Am2=(NH3) 2, ethylenediamine (en), 1, 2- diaminocyclohexane (DACH) or (NH3)(c-C6H11NH2) and where L is a bidentate 1, 1- dicarboxylate ligand tethered to 1-aminoanthraquinone by various spacers] was prepared and screened in vitro against P388 leukemia cells. The free ligands displayed moderate activity and the corresponding platinum complexes were tenfold more active. The nature ...